Article

Nucleotide Excision Repair of Aflatoxin-induced DNA Damage within the 3D Human Genome Organization

2023-09-29

Abstract excerpt

<h4>ABSTRACT</h4> Aflatoxin B1 (AFB1), a potent mycotoxin, is one of the two primary risk factors that cause liver cancer. In the liver, the bioactivated AFB1 intercalates into the DNA double helix to form a bulky DNA adduct which will lead to mutation if left unrepaired. We have adapted the tXR-seq method to measure the nucleotide excision repair of AFB1-induced DNA adducts. We have found that transcription-coup...

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Literature Corpus work: 03eab7ea-9a81-54d0-a9dd-735dca7c0edd
DOI: 10.1101/2023.09.27.559858

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