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Article

Cell non-autonomy amplifies disruption of neurulation by mosaic Vangl2 deletion

2020-09-09

Abstract excerpt

<title>Abstract</title> <p>Post-zygotic mutations that generate tissue mosaicism are increasingly associated with severe congenital defects, including those arising from failed neural tube closure. We observed that elevation of the neural folds during mouse spinal neurulation is vulnerable to deletion of the planar cell polarity core component Van Gogh-like (Vangl)2 in as few as 16% of neuroepithelial cells. Vang...

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Literature Corpus work
e40e9691-3156-5e1e-acf9-da476da14ad0
DOI
10.21203/rs.3.rs-73706/v1
Open publication

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Cell non-autonomy amplifies disruption of neurulation by mosaic Vangl2 deletionDOI 10.21203/rs.3.rs-73706/v1
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