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Pathogenesis of neural tube defects: The regulation and disruption of cellular processes underlying neural tube closure

3 May 2022

Abstract excerpt

Neural tube closure (NTC) is crucial for proper development of the brain and spinal cord and requires precise morphogenesis from a sheet of cells to an intact three-dimensional structure. NTC is dependent on successful regulation of hundreds of genes, a myriad of signaling pathways, concentration gradients, and is influenced by epigenetic and environmental cues. Failure of NTC is termed a neural tube defect (NTD)...

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PMID: 35504597
DOI: 10.1002/wsbm.1559

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