Article

Severe neural tube defects due to failure of closure initiation can arise without abnormality of neuroepithelial convergent extension

2021-07-04

Abstract excerpt

<h4>ABSTRACT</h4> Planar cell polarity (PCP) signalling is vital for initiation of neural tube closure in mice, with diminished convergent extension (CE) cell movements leading to a severe form of neural tube defect (NTD), termed craniorachischisis (CRN). Some human NTDs are also associated with PCP gene mutations, but affected individuals are generally heterozygous, whereas PCP homozygosity or compound heterozyg...

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Literature Corpus work: 70b24347-a8e1-573e-9380-bede69581559
DOI: 10.1101/2021.07.04.451044

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