Article
Loss of membrane targeting of Vangl proteins causes neural tube defects.
Biochemistry - 8 Feb 2011
Iliescu Alexandra, Gravel Michel, Horth Cynthia, Kibar Zoha, Gros Philippe
Abstract excerpt
In the mouse, the loop-tail mutation (Lp) causes a very severe neural tube defect, which is caused by mutations in the Vangl2 gene. In mammals, Vangl1 and Vangl2 code for integral membrane proteins that assemble into asymmetrically distributed membrane complexes that establish planar cell polarity in epithelial cells and that regulate convergent extension movements during embryogenesis. To date, VANGL are the...
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