Article
Cell non-autonomy amplifies disruption of neurulation by mosaic Vangl2 deletion in mice.
Nature communications - 19 Feb 2021
Galea Gabriel L, Maniou Eirini, Edwards Timothy J, Marshall Abigail R, Ampartzidis Ioakeim, Greene Nicholas D E, Copp Andrew J
Abstract excerpt
Post-zygotic mutations that generate tissue mosaicism are increasingly associated with severe congenital defects, including those arising from failed neural tube closure. Here we report that neural fold elevation during mouse spinal neurulation is vulnerable to deletion of the VANGL planar cell polarity protein 2 (Vangl2) gene in as few as 16% of neuroepithelial cells. Vangl2-deleted cells are typically dispersed...
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