Article

Tissue-wide Effects Overrule Cell-intrinsic Gene Function in Cortical Projection Neuron Migration

2022-02-17

Abstract excerpt

<h4>ABSTRACT</h4> The mammalian neocortex is composed of diverse neuronal and glial cell classes that broadly arrange in six distinct laminae. Cortical layers emerge during development and defects in the developmental programs that orchestrate cortical lamination are associated with neurodevelopmental diseases. The developmental principle of cortical layer formation is based on concerted radial projection neuron...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4cb09c96-b1eb-5256-a9c0-a1328f282fba
DOI: 10.1101/2022.02.16.480659

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tissue-wide Effects Overrule Cell-intrinsic Gene Function in Cortical Projection Neuron MigrationDOI 10.1101/2022.02.16.480659Read

Cortical neuronal migration mutants suggest separate but intersecting pathways.Semantic proximity Read

Performing Single-Cell Clonal Analysis in the Mouse Brain Using Mosaic Analysis with Double Markers (MADM).Semantic proximity Read

<i>Pten</i> Orchestrates Neurogenic Radial Glia Lineage Progression and Tunes Neocortical Astrocyte ProductionSemantic proximity Read

WDFY3 cell autonomously controls neuronal migrationSemantic proximity Read

Genetic mosaic analysis in the nervous system.Semantic proximity Read

Mosaic analysis with double markers (MADM) in mice.Semantic proximity Read

Somatic Mosaicism Patterns Define Clinical-Surgical Subtypes of Focal Cortical Dysplasia Through Cell-Type-Specific ExpressionSemantic proximity Read

<i>DLG2</i> knockout reveals neurogenic transcriptional programs underlying neuropsychiatric disorders and cognitionSemantic proximity Read

Phenotypic analysis with trans-recombination-based genetic mosaic models.Semantic proximity Read

WDFY3 mutation alters laminar position and morphology of cortical neurons.Semantic proximity Read

Probing Cell-Type Specificity of Mutant Phenotype at Transcriptomic Level Using Mosaic Analysis with Double Markers (MADM).Semantic proximity Read

Spatial Perturb-Seq: Single-Cell Functional Genomics within Intact Tissue ArchitectureSemantic proximity Read