Article

Neural tube closure requires the endocytic receptor Lrp2 and its functional interaction with intracellular scaffolds

2020-07-16

Abstract excerpt

Recent studies have revealed that pathogenic mutations in the endocytic receptor LRP2 in humans are associated with severe neural tube closure defects (NTDs) such as anencephaly and spina bifida. Here, we combined analysis of neural tube closure in mouse and in the African Clawed Frog Xenopus laevis to elucidate the etiology of Lrp2-related NTDs. Lrp2 loss-of-function (LOF) impaired neuroepithelial morphogenesis...

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Literature Corpus work: 448812dd-bbc5-55e5-ac3d-c63cab4f70e2
DOI: 10.1101/2020.07.15.205252

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