Apurinic endonuclease-1 preserves neural genome integrity to maintain homeostasis and thermoregulation and prevent brain tumors

Abstract excerpt

Significance The nervous system consumes a large quotient of oxygen and as such is at risk for high levels of oxidative DNA damage. A key DNA-repair factor, apurinic/apyrimidinic endonuclease 1 (APE1), is essential for repair of oxidative DNA lesions, although the specific role(s) for this enzyme in the nervous system is unknown. Surprisingly, mice lacking APE1 throughout neurogenesis were viable and showed...

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