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XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair

22 Nov 2021

Abstract excerpt

Abstract Genetic defects in the repair of DNA single-strand breaks (SSBs) can result in neurological disease triggered by toxic activity of the single-strand-break sensor protein PARP1. However, the mechanism(s) by which this toxic PARP1 activity triggers cellular dysfunction are unclear. Here we show that human cells lacking XRCC1 fail to rapidly recover transcription following DNA base damage, a phenotype also...

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PMID: 34811483
DOI: 10.1038/s41556-021-00792-w

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