Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional dissection of H3K4 methyltransferases reveals distinct catalytic and non-catalytic roles in C. elegans development.

Development (Cambridge, England) - 1 Nov 2025

Attianese Benedetta, Wang Hua, Madsen Katrine, Zeijdner Mandoh, Helin Kristian, Abay-Nørgaard Steffen, Salcini Anna Elisabetta

Abstract excerpt

The KMT2 class of histone methyltransferases regulates methylation of histone 3 lysine 4 (H3K4), a conserved post-translational modification associated with active transcription. However, previous studies have highlighted catalytic-independent functions of KMT2 members and questioned the influence of H3K4 methylation on gene expression. Here, we address this by generating catalytically inactive mutants of SET-2...

Topics

Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Histone-Lysine N-Methyltransferase
Histones
Methylation
Gene Expression Regulation, Developmental
Mutation
Nuclear Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 41122790
DOI: 10.1242/dev.204924
PMCID: PMC12633793

Genes

SET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-41122790-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional dissection of H3K4 methyltransferases reveals distinct catalytic and non-catalytic roles in C. elegans development.PMID 41122790Read ↗

SETDB1-like MET-2 promotes transcriptional silencing and development independently of its H3K9me-associated catalytic activity.Semantic proximity Read ↗

WDR-5 exhibits H3K4 methylation-independent activity during embryonic development in C. elegansSemantic proximity Read ↗

KMT2C knockout generates ASD-like behaviors in miceSemantic proximity Read ↗

Distinct developmental phenotypes result from mutation of Set8/KMT5A and histone H4 lysine 20 in <i>Drosophila melanogaster</i>Semantic proximity Read ↗

Distinct developmental phenotypes result from mutation of Set8/KMT5A and histone H4 lysine 20 in Drosophila melanogaster.Semantic proximity Read ↗

A SET domain-containing protein and HCF-1 maintain transgenerational epigenetic memorySemantic proximity Read ↗

A SET domain-containing protein and HCF-1 maintain transgenerational epigenetic memory.Semantic proximity Read ↗

Histone methyltransferase MET-2 differentially regulates autosome and X-chromosome structure and transcription during meiosis in <i>C. elegans</i>Semantic proximity Read ↗

Enrichment of H3K9me2 on Unsynapsed Chromatin in Caenorhabditis elegans Does Not Target de Novo Sites.Semantic proximity Read ↗

The <i>C. elegans</i> SET-2 histone methyltransferase maintains germline fate by preventing progressive transcriptomic deregulation across generationsSemantic proximity Read ↗

SUMO-mediated regulation of H3K4me3 reader SET-26 controls germline development in C. elegans.Semantic proximity Read ↗

The histone chaperone activity of SPT2 controls chromatin structure and function in MetazoaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.