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Article

Maternal histone methyltransferases antagonistically regulate autosomal random monoallelic expression (aRMAE) in C. elegans.

Nature communications - 28 Nov 2025

Sands Bryan, Yun Soo R, Oshima Junko, Mendenhall Alexander R

Abstract excerpt

Undefined epigenetic programs act to probabilistically silence individual autosomal alleles, generating unique individuals, even from genetic clones. This random monoallelic expression can explain variation in traits and diseases that differences in genes and environments cannot. Here, we developed the nematode Caenorhabditis elegans to study monoallelic expression in whole tissues, and defined a developmental...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41315265
DOI: 10.1038/s41467-025-66501-5
PMCID: PMC12753696

Genes

SET
MET
ARL14EP
ATF7IP
L3MBTL2
SETDB1

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