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The mutational features of aristolochic acid-induced mouse and human liver cancers

2018-12-28

Abstract excerpt

Aristolochic acid (AA) derived from traditional Chinese herbal remedies has recently been statistically associated with human liver cancer; however, the causal relationships between AA and liver cancer and the underlying evolutionary process of AA-mediated mutagenesis during tumorigenesis are obscure. Here, we subjected mice, including Pten -deficient ones, to aristolochic acid I (AAI) alone or a combination of A...

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Literature Corpus work
e3b0f169-c603-5bf4-ad36-766e05e8bfaa
DOI
10.1101/507301
Open publication

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