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Hepatic Premalignant Alterations Triggered by Human Nephrotoxin Aristolochic Acid I in Canines

6 Feb 2016

Abstract excerpt

Aristolochic acid I (AAI) existing in plant drugs from Aristolochia species is an environmental human carcinogen associated with urothelial cancer. Although gene association network analysis demonstrated gene expression profile changes in the liver of human TP53 knock-in mice after acute AAI exposure, to date, whether AAI causes hepatic tumorigenesis is still not confirmed. Here, we show that hepatic premalignant...

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PMID: 26851235
DOI: 10.1158/1940-6207.capr-15-0339

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