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Aristolochic acids exposure was not the main cause of liver tumorigenesis in adulthood

16 Nov 2021

Abstract excerpt

Aristolochic acids (AAs) have long been considered as a potent carcinogen due to its nephrotoxicity. Aristolochic acid I (AAI) reacts with DNA to form covalent aristolactam (AL)-DNA adducts, leading to subsequent A to T transversion mutation, commonly referred as AA mutational signature. Previous research inferred that AAs were widely implicated in liver cancer throughout Asia. In this study, we explored whether...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35646530
DOI: 10.1016/j.apsb.2021.11.011

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