Genome-wide mutational signatures of aristolochic acid and its application as a screening tool.

doi:10.1126/scitranslmed.3006086

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Article

Genome-wide mutational signatures of aristolochic acid and its application as a screening tool.

Science translational medicine - 7 Aug 2013

Poon Song Ling, Pang See-Tong, McPherson John R, Yu Willie, Huang Kie Kyon, Guan Peiyong, Weng Wen-Hui, Siew Ee Yan, Liu Yujing, Heng Hong Lee, Chong Soo Ching, Gan Anna, Tay Su Ting, Lim Weng Khong, Cutcutache Ioana, Huang Dachuan, Ler Lian Dee, Nairismägi Maarja-Liisa, Lee Ming Hui, Chang Ying-Hsu, Yu Kai-Jie, Chan-On Waraporn, Li Bin-Kui, Yuan Yun-Fei, Qian Chao-Nan, Ng Kwai-Fong, Wu Ching-Fang, Hsu Cheng-Lung, Bunte Ralph M, Stratton Michael R, Futreal P Andrew, Sung Wing-Kin, Chuang Cheng-Keng, Ong Choon Kiat, Rozen Steven G, Tan Patrick, Teh Bin Tean

Abstract excerpt

Aristolochic acid (AA), a natural product of Aristolochia plants found in herbal remedies and health supplements, is a group 1 carcinogen that can cause nephrotoxicity and upper urinary tract urothelial cell carcinoma (UTUC). Whole-genome and exome analysis of nine AA-associated UTUCs revealed a...

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PMID: 23926199
DOI: 10.1126/scitranslmed.3006086

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23926199-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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