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Whether aristolochic acid directly drives hepatocarcinogenesis: comprehensive investigations from mutational signatures to animal models.

Archives of toxicology - 1 Sept 2025

Yang Lu, Lin Wanjun, Shi Meina, Huang Zifeng, Zhang Xuening, Yang Yanchao, Chu Tong, Zheng Dayuan, Yang Dongfan, Ma Wenzhe

Abstract excerpt

Aristolochic Acid (AA) is a class of naturally occurring compounds characterized by potent genotoxicity and carcinogenicity, predominantly found in plants of the Aristolochia genus. The 1993 Belgian weight-loss incident and subsequent research unequivocally established the association between AA and "Aristolochic Acid Nephropathy" (AAN) as well as Balkan Endemic Nephropathy (BEN), prompting global regulatory...

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PMID: 40445366
DOI: 10.1007/s00204-025-04087-z

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Whether aristolochic acid directly drives hepatocarcinogenesis: comprehensive investigations from mutational signatures to animal models.PMID 40445366Read ↗

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