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Article

DNA adduct formation and mutation induction by aristolochic acid in rat kidney and liver.

Mutation research - 1 Dec 2006

Mei Nan, Arlt Volker M, Phillips David H, Heflich Robert H, Chen Tao

Abstract excerpt

Aristolochic acid (AA) is a potent nephrotoxin and carcinogen and is the causative factor for Chinese herb nephropathy. AA has been associated with the development of urothelial cancer in humans, and kidney and forestomach tumors in rodents. To investigate the molecular mechanisms responsible for the tumorigenicity of AA, we determined the DNA adduct formation and mutagenicity of AA in the liver (nontarget...

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Identifiers

PMID: 17010389
DOI: 10.1016/j.mrfmmm.2006.08.004
PMCID: PMC6370021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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