Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia.

Science translational medicine - 18 Oct 2017

Ng Alvin W T, Poon Song Ling, Huang Mi Ni, Lim Jing Quan, Boot Arnoud, Yu Willie, Suzuki Yuka, Thangaraju Saranya, Ng Cedric C Y, Tan Patrick, Pang See-Tong, Huang Hao-Yi, Yu Ming-Chin, Lee Po-Huang, Hsieh Sen-Yung, Chang Alex Y, Teh Bin T, Rozen Steven G

Abstract excerpt

Many traditional pharmacopeias include Aristolochia and related plants, which contain nephrotoxins and mutagens in the form of aristolochic acids and similar compounds (collectively, AA). AA is implicated in multiple cancer types, sometimes with very high mutational burdens, especially in upper tract urothelial cancers (UTUCs). AA-associated kidney failure and UTUCs are prevalent in Taiwan, but AA's role in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asia
Share to Geography

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunotherapy

Share to Liver Neoplasms

Share to Mutagenesis

Share to Mutation

Share to Taiwan

Source

Identifiers

PMID: 29046434
DOI: 10.1126/scitranslmed.aan6446

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia.PMID 29046434Read ↗

Whether aristolochic acid directly drives hepatocarcinogenesis: comprehensive investigations from mutational signatures to animal models.Semantic proximity Read ↗

Aristolochic acid-induced upper tract urothelial carcinoma in Taiwan: clinical characteristics and outcomes.Semantic proximity Read ↗

Aristolochic Acid in the Etiology of Renal Cell Carcinoma.Semantic proximity Read ↗

Aristolochic acid-associated urothelial cancer in TaiwanSemantic proximity Read ↗

Aristolochic acid nephropathy: Harbinger of a global iatrogenic disease.Semantic proximity Read ↗

Aristolochic acid mutational signature defines the low-risk subtype in upper tract urothelial carcinoma.Semantic proximity Read ↗

Mutational signature of aristolochic acid: Clue to the recognition of a global disease.Semantic proximity Read ↗

Renal cell carcinomas of chronic kidney disease patients harbor the mutational signature of carcinogenic aristolochic acidSemantic proximity Read ↗

Mutation signatures implicate aristolochic acid in bladder cancer developmentSemantic proximity Read ↗

High incidence of intrahepatic cholangiocarcinoma in end-stage renal disease patients in Taiwan: analysis of a nationwide database with molecular insight of aristolochic acid exposure.Semantic proximity Read ↗

Genome-wide mutational signatures of aristolochic acid and its application as a screening tool.Semantic proximity Read ↗

Unveiling correlations between aristolochic acids and liver cancer: spatiotemporal heterogeneity phenomenonSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.