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Long-term toxicity evaluation of aristolochic acid-IIIa in mice.

Toxicology - 1 Aug 2024

Wang Lianmei, Wang Yuan, Zhao Yong, Li Chunying, Yi Yan, Tian Jingzhuo, Li Guiqin, Xian Zhong, Wang Fang, Meng Jing, Zhang Yushi, Han Jiayin, Pan Chen, Liu Suyan, Liu Meiting, Liu Chenyue, Liang Aihua

Abstract excerpt

Aristolochic acid (AA)-IIIa is an AA analog present in Aristolochiaceae plants. To evaluate the chronic toxicity of AA-IIIa, mice were intragastrically administered with media control, 1 mg/kg AA-IIIa, and 10 mg/kg AA-IIIa, and designated as the control (CTL), AA-IIIa low dose (AA-IIIa-L), and AA-IIIa high dose (AA-IIIa-H) groups, respectively. AA-IIIa was administered three times a week, every other day, for 24...

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PMID: 38797228
DOI: 10.1016/j.tox.2024.153838

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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