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Article

The Mutational Features of Aristolochic Acid-Induced Mouse and Human Liver Cancers.

Hepatology (Baltimore, Md.) - 1 Mar 2020

Lu Zhao-Ning, Luo Qing, Zhao Li-Nan, Shi Yi, Wang Na, Wang Lan, Han Ze-Guang

Abstract excerpt

BACKGROUND AND AIMS: Aristolochic acid (AA) exposure has been statistically associated with human liver cancers. However, direct evidence of AA exposure-induced liver cancer is absent. This study aims to establish a direct causal relationship between AA exposure and liver cancers based on a mouse model and then explores the AA-mediated genomic alterations that could be implicated in human cancers with...

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PMID: 31692012
DOI: 10.1002/hep.30863

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