Article

Single-cell epigenetic analysis reveals principles of chromatin states in H3.3-K27M gliomas

2021-11-04

Abstract excerpt

<h4>Summary</h4> Cancer cells are highly heterogeneous at the transcriptional level and in their epigenetic state. Methods to study epigenetic heterogeneity are limited in throughput and information obtained per cell. Here, we adapted Cytometry by Time of Flight (CyTOF) to analyze a wide panel of histone modifications in primary tumor-derived lines of Diffused Intrinsic Pontine Glioma (DIPG). DIPG is a lethal gli...

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Literature Corpus work: e3a3ac19-1dfb-539a-a597-8d741714115e
DOI: 10.1101/2021.11.02.466907

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