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Article

Single-cell epigenetic analysis reveals principles of chromatin states in H3.3-K27M gliomas.

Molecular cell - 21 Jul 2022

Harpaz Nofar, Mittelman Tamir, Beresh Olga, Griess Ofir, Furth Noa, Salame Tomer-Meir, Oren Roni, Fellus-Alyagor Liat, Harmelin Alon, Alexandrescu Sanda, Marques Joana Graca, Filbin Mariella G, Ron Guy, Shema Efrat

Abstract excerpt

Cancer cells are highly heterogeneous at the transcriptional level and epigenetic state. Methods to study epigenetic heterogeneity are limited in throughput and information obtained per cell. Here, we adapted cytometry by time-of-flight (CyTOF) to analyze a wide panel of histone modifications in primary tumor-derived lines of diffused intrinsic pontine glioma (DIPG). DIPG is a lethal glioma, driven by a histone...

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Identifiers

PMID: 35716669
DOI: 10.1016/j.molcel.2022.05.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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