Article
Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq.
Science (New York, N.Y.) - 20 Apr 2018
Filbin Mariella G, Tirosh Itay, Hovestadt Volker, Shaw McKenzie L, Escalante Leah E, Mathewson Nathan D, Neftel Cyril, Frank Nelli, Pelton Kristine, Hebert Christine M, Haberler Christine, Yizhak Keren, Gojo Johannes, Egervari Kristof, Mount Christopher, van Galen Peter, Bonal Dennis M, Nguyen Quang-De, Beck Alexander, Sinai Claire, Czech Thomas, Dorfer Christian, Goumnerova Liliana, Lavarino Cinzia, Carcaboso Angel M, Mora Jaume, Mylvaganam Ravindra, Luo Christina C, Peyrl Andreas, Popović Mara, Azizi Amedeo, Batchelor Tracy T, Frosch Matthew P, Martinez-Lage Maria, Kieran Mark W, Bandopadhayay Pratiti, Beroukhim Rameen, Fritsch Gerhard, Getz Gad, Rozenblatt-Rosen Orit, Wucherpfennig Kai W, Louis David N, Monje Michelle, Slavc Irene, Ligon Keith L, Golub Todd R, Regev Aviv, Bernstein Bradley E, Suvà Mario L
Abstract excerpt
Gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) arise primarily in the midline of the central nervous system of young children, suggesting a cooperation between genetics and cellular context in tumorigenesis. Although the genetics of H3K27M-glioma are well characterized, their cellular architecture remains uncharted. We performed single-cell RNA sequencing in 3321 cells from six primary...
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