Article

Shared genetic and neuroimmune architecture links type 1 diabetes with neurocognitive traits

2025-09-16

Abstract excerpt

<h4>ABSTRACT</h4> Type 1 diabetes (T1D), particularly with childhood onset, is associated with altered cognitive traits and neuropsychiatric risk, yet the biological bases remain unclear. Here, we integrate genome-wide association variants with single-cell epigenomic profiles and show that T1D heritability is enriched in accessible chromatin of human brain-resident cells, notably microglia, across neurodevelopmen...

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Literature Corpus work: e391242e-9c06-51cb-a5b1-08a1558ea73d
DOI: 10.1101/2025.09.14.25335719

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