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Article

Cell-type-specific genetic architecture reveals neuronal and immune contributions to neuropsychiatric disorders.

Molecular psychiatry - 1 Sept 2026

Wang Xinyue, Luo Lingxue, Chang Suhua, Yang Li

Abstract excerpt

Neuropsychiatric disorders exhibit complex polygenic architectures, yet the cell-type-specific mechanisms underlying most risk loci remain unclear. Here, we integrate single-cell expression quantitative trait locus (sc-eQTL) data from brain and blood tissues with genome-wide association studies (GWAS) of six neuropsychiatric disorders (schizophrenia (SCZ), Parkinson's disease (PD), bipolar disorder (BP), major...

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Identifiers

PMID: 42020718
DOI: 10.1038/s41380-026-03606-3

Genes

APTX
FLOT1
MAPT

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