Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes.

doi:10.1038/s41588-021-00880-5

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Article

Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes.

Nature genetics - 1 Jul 2021

Robertson Catherine C, Inshaw Jamie R J, Onengut-Gumuscu Suna, Chen Wei-Min, Santa Cruz David Flores, Yang Hanzhi, Cutler Antony J, Crouch Daniel J M, Farber Emily, Bridges S Louis, Edberg Jeffrey C, Kimberly Robert P, Buckner Jane H, Deloukas Panos, Divers Jasmin, Dabelea Dana, Lawrence Jean M, Marcovina Santica, Shah Amy S, Greenbaum Carla J, Atkinson Mark A, Gregersen Peter K, Oksenberg Jorge R, Pociot Flemming, Rewers Marian J, Steck Andrea K, Dunger David B, Wicker Linda S, Concannon Patrick, Todd John A, Rich Stephen S

Abstract excerpt

We report the largest and most diverse genetic study of type 1 diabetes (T1D) to date (61,427 participants), yielding 78 genome-wide-significant (P < 5 × 10-8) regions, including 36 that are new. We define credible sets of T1D-associated variants and show that they are enriched in immune-cell accessible chromatin, particularly CD4+ effector T cells. Using chromatin-accessibility profiling of CD4+ T cells from 115...

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PMID: 34127860
DOI: 10.1038/s41588-021-00880-5
PMCID: PMC8273124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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