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Article

Shared genetic and neuroimmune architecture links type 1 diabetes with neurocognitive traits.

Nature communications - 13 Mar 2026

Saarah Priscilla, Syeda Zehra A, Xu Ziang, Dong Yikai, Jiang Habei, Shanguhyia Michelle, Roy Sourav, Zhu Biqing, Zhang Le, Dewan Andrew T, Asgari Samira, Alagpulinsa David A

Abstract excerpt

Type 1 diabetes, particularly with childhood onset, is associated with altered neurocognitive traits, yet the underlying biological mechanisms are unclear. Here, we integrate genome-wide association results with single-cell epigenomic profiles and show that type 1 diabetes heritability is enriched in accessible chromatin of human brain-resident cells, most notably microglia, across neurodevelopment into...

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Identifiers

PMID: 41826324
DOI: 10.1038/s41467-026-70694-8
PMCID: PMC13139607

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