Article

Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes

2020-06-20

Abstract excerpt

We report the largest and most ancestrally diverse genetic study of type 1 diabetes (T1D) to date (61,427 participants), yielding 152 regions associated to false discovery rate < 0.01, including 36 regions associated to genome-wide significance for the first time. Credible sets of disease-associated variants are specifically enriched in immune cell accessible chromatin, particularly in CD4 + effector T cells. Col...

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Literature Corpus work: 0ecae434-10f6-5db1-89fd-aad748f0b99e
DOI: 10.1101/2020.06.19.158071

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