Article
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
PLoS genetics - 1 Sept 2011
Bradfield Jonathan P, Qu Hui-Qi, Wang Kai, Zhang Haitao, Sleiman Patrick M, Kim Cecilia E, Mentch Frank D, Qiu Haijun, Glessner Joseph T, Thomas Kelly A, Frackelton Edward C, Chiavacci Rosetta M, Imielinski Marcin, Monos Dimitri S, Pandey Rahul, Bakay Marina, Grant Struan F A, Polychronakos Constantin, Hakonarson Hakon
Abstract excerpt
Diabetes impacts approximately 200 million people worldwide, of whom approximately 10% are affected by type 1 diabetes (T1D). The application of genome-wide association studies (GWAS) has robustly revealed dozens of genetic contributors to the pathogenesis of T1D, with the most recent meta-analysis identifying in excess of 40 loci. To identify additional genetic loci for T1D susceptibility, we examined...
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