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Article

Sodium taurocholate cotransporting polypeptide (NTCP) polymorphisms may influence HDV RNA load and early response to bulevirtide.

Journal of hepatology - 1 Nov 2024

Toniutto Pierluigi, Falleti Edmondo, Cmet Sara, Cussigh Annarosa, Degasperi Elisabetta, Anolli Maria Paola, Sambarino Dana, Facchetti Floriana, Borghi Marta, Perbellini Riccardo, Monico Sara, Lampertico Pietro

Abstract excerpt

BACKGROUND & AIMS: Genetic polymorphisms in the sodium taurocholate cotransporting peptide (NTCP encoded by SLC10A1) have been described, but their role in untreated and treated patients with chronic hepatitis delta (CHD) remains unknown. Virological response (VR) to the NTCP inhibitor bulevirtide (BLV) was achieved at week 48 by >70% of patients with CHD, but nearly 15% experienced virological non-response (VNR)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38901675
DOI: 10.1016/j.jhep.2024.06.013

Genes

IMPACT
SLC10A1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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