Article
Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor.
Proceedings of the National Academy of Sciences of the United States of America - 25 Sept 2018
Nelson Christopher A, Wilen Craig B, Dai Ya-Nan, Orchard Robert C, Kim Arthur S, Stegeman Roderick A, Hsieh Leon L, Smith Thomas J, Virgin Herbert W, Fremont Daved H
Abstract excerpt
Murine norovirus (MNoV) is closely related to human norovirus (HNoV), an infectious agent responsible for acute gastroenteritis worldwide. Here we report the X-ray crystal structure of the dimeric MNoV VP1 protruding (P) domain in complex with its cellular receptor CD300lf. CD300lf binds the P domain with a 2:2 stoichiometry, engaging a cleft between the AB and DE loops of the P2 subdomain at a site that overlaps...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.