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Article

A targeted functional RNA interference screen uncovers glypican 5 as an entry factor for hepatitis B and D viruses

30 Jul 2015

Abstract excerpt

UNLABELLED: Chronic hepatitis B and D infections are major causes of liver disease and hepatocellular carcinoma worldwide. Efficient therapeutic approaches for cure are absent. Sharing the same envelope proteins, hepatitis B virus and hepatitis delta virus use the sodium/taurocholate cotransporting polypeptide (a bile acid transporter) as a receptor to enter hepatocytes. However, the detailed mechanisms of the...

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PMID: 26224662
DOI: 10.1002/hep.28013

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