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Interferon-gamma induced RNF213 targets nascent double membrane vesicles to inhibit coronavirus primary translation

2026-06-04

Abstract excerpt

Innate immune systems employ many mechanisms to inhibit the replication of viruses that profoundly affect host range and pathogenicity. To identify proteins that restrict human respiratory virus replication, we executed CRISPR screens targeting both type-I and type-II interferon stimulated genes. Among the candidate antiviral genes identified, the giant ring finger protein 213 (RNF213) was a key mediator of antivi...

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Literature Corpus work
e3290ff9-e1c8-581a-81e2-d2462ee7eaf9
DOI
10.64898/2026.06.02.729663
Open publication

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Interferon-gamma induced RNF213 targets nascent double membrane vesicles to inhibit coronavirus primary translationDOI 10.64898/2026.06.02.729663
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