Article

High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins

2021-03-02

Abstract excerpt

<h4>Summary</h4> Suppression of the host intracellular innate immune system is an essential aspect of viral replication. Here, we developed a suite of medium-throughput high-content cell-based assays to reveal the effect of individual coronavirus proteins on antiviral innate immune pathways. Using these assays, we screened the 196 protein products of seven coronaviruses (SARS-CoV-2, SARS-CoV-1, 229E, NL63, OC43,...

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Literature Corpus work: 97f57067-1ba9-5915-99bc-171eb3a13ff5
DOI: 10.1101/2021.03.02.433434

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