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Interferon regulatory factor 3 mediates effective antiviral responses to human coronavirus 229E and OC43 infection

1 May 2023

Abstract excerpt

Interferon regulatory factors (IRFs) are key elements of antiviral innate responses that regulate the transcription of interferons (IFNs) and IFN-stimulated genes (ISGs). While the sensitivity of human coronaviruses to IFNs has been characterized, antiviral roles of IRFs during human coronavirus infection are not fully understood. Type I or II IFN treatment protected MRC5 cells from human coronavirus 229E...

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PMID: 37197656
DOI: 10.3389/fimmu.2023.930086

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