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Article

Coronavirus Endoribonuclease and Deubiquitinating Interferon Antagonists Differentially Modulate the Host Response during Replication in Macrophages.

Journal of virology - 18 May 2020

Volk Aaron, Hackbart Matthew, Deng Xufang, Cruz-Pulido Yazmin, O'Brien Amornrat, Baker Susan C

Abstract excerpt

Coronaviruses (CoVs) encode multiple interferon (IFN) antagonists that modulate the host response to virus replication. Here, we evaluated the host transcriptional response to infection with murine coronaviruses encoding independent mutations in one of two different viral antagonists, the deubiquitinase (DUB) within nonstructural protein 3 or the endoribonuclease (EndoU) within nonstructural protein 15. We used...

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Source

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Identifiers

PMID: 32188729
DOI: 10.1128/JVI.00178-20
PMCID: PMC7269425

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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