Article

Identification of anti-norovirus genes in mouse and human cells using genome-wide CRISPR activation screening

2018-06-18

Abstract excerpt

Noroviruses (NoVs) are a leading cause of gastroenteritis world-wide, yet host factors that restrict NoV replication are not well understood. Here, we use a CRISPR activation (CRISPRa) genome-wide screening to identify host genes that can inhibit murine norovirus (MNoV) replication in either mouse or human cells. Our screens identified with high confidence 57 genes that can inhibit MNoV infection when overexpresse...

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Literature Corpus work: 447dc0eb-ab0b-5098-b282-396e614287e3
DOI: 10.1101/350090

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