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Genome-wide and targeted CRISPR screens identify RNF213 as a mediator of interferon gamma–dependent pathogen restriction in human cells

26 Dec 2023

Abstract excerpt

To define cellular immunity to the intracellular pathogen Toxoplasma gondii , we performed a genome-wide CRISPR loss-of-function screen to identify genes important for (interferon gamma) IFN-γ-dependent growth restriction. We revealed a role for the tumor suppressor NF2/Merlin for maximum induction of Interferon Stimulated Genes (ISG), which are positively regulated by the transcription factor IRF-1. We then...

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PMID: 38147552
DOI: 10.1073/pnas.2315865120

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