Article

RCAN1 Knockout and Overexpression Recapitulate an Ensemble of Rest-activity and Circadian Disruptions Characteristic of Down Syndrome, Alzheimer’s Disease, and Normative Aging

2021-11-10

Abstract excerpt

<title>Abstract</title> <p>Background: <italic>Regulator of calcineurin 1 (RCAN1)</italic> is overexpressed in Down syndrome (DS), but RCAN1 levels are also increased in Alzheimer's disease (AD) and normal aging. AD is highly comorbid among individuals with DS and is characterized in part by progressive neurodegeneration that resembles accelerated aging. Importantly, abnormal RCAN1 levels have been demonstrated t...

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Literature Corpus work: e3123c6b-5b00-50f6-8eaa-6d62c83a34f9
DOI: 10.21203/rs.3.rs-1032228/v1

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