Article

Circadian rhythms and the light-dark cycle interact to regulate amyloid plaque accumulation and tau phosphorylation in 5xFAD mice

2025-04-04

Abstract excerpt

<h4>Background</h4> Circadian disruption has long been appreciated as a downstream consequence of Alzheimer’s Disease in humans. However, an upstream role for behavioral circadian disruption in regulating AD pathology remains an open question. <h4>Methods</h4> To determine the role of the central circadian clock in the suprachiasmatic nucleus (SCN) in regulating amyloid pathology, we generated mice harboring del...

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Literature Corpus work: 21aec14d-d1d0-53e9-99c3-15e194d4566d
DOI: 10.1101/2025.03.31.645805

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