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Article

Reversible suppression of circadian-driven locomotor rhythms in mice using a gradual fragmentation of the day-night cycle.

Scientific reports - 2 Sept 2023

Richardson Melissa E S, Browne Chérie-Akilah, Mazariegos Citlali I Huerta

Abstract excerpt

Circadian rhythms are regulated by molecular clockwork and drive 24-h behaviors such as locomotor activity, which can be rendered non-functional through genetic knockouts of clock genes. Circadian rhythms are robust in constant darkness (DD) but are modulated to become exactly 24 h by the external day-night cycle. Whether ill-timed light and dark exposure can render circadian behaviors non-functional to the...

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Identifiers

PMID: 37660212
DOI: 10.1038/s41598-023-41029-0
PMCID: PMC10475134

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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