Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The neuronal and endocrine roles of RCAN 1 in health and disease

2 Nov 2017

Abstract excerpt

The regulator of calcineurin 1 (RCAN1) was first discovered as a gene located on human chromosome 21, expressed in neurons and overexpressed in the brains of Down syndrome individuals. Increased expression of RCAN1 has been linked with not only Down syndrome-associated pathology but also an associated neurological disorder, Alzheimer's Disease, in which neuronal RCAN1 expression is also increased. RCAN1 has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neuropeptides and Animal Physiology
Share to Pancreatic function and diabetes
Share to Signaling Pathways in Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29094385
DOI: 10.1111/1440-1681.12884

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The neuronal and endocrine roles of RCAN 1 in health and diseasePMID 29094385Read ↗

RCAN1 (DSCR1) increases neuronal susceptibility to oxidative stress: a potential pathogenic process in neurodegeneration.Semantic proximity Read ↗

Two key genes closely implicated with the neuropathological characteristics in Down syndrome: DYRK1A and RCAN1Semantic proximity Read ↗

RCAN1 Knockout and Overexpression Recapitulate an Ensemble of Rest-activity and Circadian Disruptions Characteristic of Down Syndrome, Alzheimer’s Disease, and Normative AgingSemantic proximity Read ↗

Multiple roles of the DSCR1 (Adapt78 or RCAN1) gene and its protein product Calcipressin 1 (or RCAN1) in diseaseSemantic proximity Read ↗

Comprehensive insights into the function and molecular and pharmacological regulation of neuron-derived orphan receptor 1, an orphan receptorSemantic proximity Read ↗

Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome.Semantic proximity Read ↗

Regulation of RCAN1 Protein Activity by Dyrk1A Protein-mediated PhosphorylationSemantic proximity Read ↗

Regulator of Calcineurin (RCAN1-1L) Is Deficient in Huntington Disease and Protective against Mutant Huntingtin Toxicity in VitroSemantic proximity Read ↗

The Caenorhabditis elegans homologue of Down syndrome critical region 1, RCN-1, inhibits multiple functions of the phosphatase calcineurin.Semantic proximity Read ↗

Regulator of Calcineurin (RCAN): Beyond Down Syndrome Critical Region.Semantic proximity Read ↗

DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathwaysSemantic proximity Read ↗

Alzheimer's disease and endocytic dysfunction: Clues from the Down syndrome-related proteins, DSCR1 and ITSN1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.