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Article

Circadian wheel running behavior is altered in an APP/E4 mouse model of late onset Alzheimer's disease.

Physiology & behavior - 1 Dec 2017

Boggs Katelyn N, Kakalec Peter A, Smith Meghann L, Howell Stefanie N, Flinn Jane M

Abstract excerpt

Circadian rhythms are altered in several diseases associated with aging, one of which is Alzheimer's disease (AD). One example of a circadian rhythm is the rest-activity cycle, which can be measured in mice by monitoring their wheel-running. The present study sought to investigate differences in light phase/dark phase activity between a mouse model of late onset AD (APP/E4) and control (C57Bl6J) mice, in both the...

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Source

Identifiers

PMID: 28958954
DOI: 10.1016/j.physbeh.2017.09.021

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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