Article

Insulin signaling regulates R2 retrotransposon expression to orchestrate transgenerational rDNA copy number maintenance

2024-02-29

Abstract excerpt

Preserving a large number of essential yet highly unstable ribosomal DNA (rDNA) repeats is critical for the germline to perpetuate the genome through generations. Spontaneous rDNA loss must be countered by rDNA copy number (CN) expansion. Germline rDNA CN expansion is best understood in Drosophila melanogaster , which relies on unequal sister chromatid exchange (USCE) initiated by DNA breaks at rDNA. The rDNA-spe...

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Literature Corpus work: e309fb8a-abbe-5cb8-a575-83d6dbce3fdf
DOI: 10.1101/2024.02.28.582629

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