Article
Insights into ribosomal DNA dominance and magnification through characterization of isogenic deletion alleles.
Genetics - 8 Jul 2024
Kindelay Selina M, Maggert Keith A
Abstract excerpt
The major loci for the large primary ribosomal RNA (rRNA) genes (35S rRNAs) exist as hundreds to thousands of tandem repeats in all organisms and dozens to hundreds in Drosophila. The highly repetitive nature of the ribosomal DNA (rDNA) makes it intrinsically unstable, and many conditions arise from the reduction in or magnification of copy number, but the conditions under which it does so remain unknown. By...
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