Article
Retrotransposons as epigenetic mediators of phenotypic variation in mammals.
Nature genetics - 1 Apr 2001
Whitelaw E, Martin D I
Abstract excerpt
Phenotypic variation in mammals is frequently attributed to the action of quantitative trait loci (QTL) or the environment, but may also be epigenetic in origin. Here we consider a mechanism for phenotypic variation based on interference of transcription by somatically active retrotransposons. Transcriptionally competent retrotransposons may number in the tens of thousands in mammalian genomes. We propose that...
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