Article

piRNAs regulate a Hedgehog germline-to-soma pro-aging signal

2021-08-09

Abstract excerpt

The reproductive system regulates the aging of the soma through competing anti- and pro-aging signals. Germline removal extends somatic lifespan through conserved pathways including Insulin, mTOR, and steroid signaling, while germline hyperactivity cuts lifespan short through mechanisms that remain elusive. Here, we show that mating-induced germline hyperactivity leads to the dramatic downregulation of piRNAs, whi...

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Identifiers and source

Literature Corpus work: eb5dafbf-0925-5344-b81c-5d71be9194f2
DOI: 10.1101/2021.08.09.455665

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