Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transgenerational dynamics of rDNA copy number in Drosophila male germline stem cells.

eLife - 13 Feb 2018

Lu Kevin L, Nelson Jonathan O, Watase George J, Warsinger-Pepe Natalie, Yamashita Yukiko M

Abstract excerpt

rDNA loci, composed of hundreds of tandemly duplicated arrays of rRNA genes, are known to be among the most unstable genetic elements due to their repetitive nature. rDNA instability underlies aging (replicative senescence) in yeast cells, however, its contribution to the aging of multicellular organisms is poorly understood. In this study, we investigate the dynamics of rDNA loci during aging in the Drosophila...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to DNA, Ribosomal
Share to Drosophila

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Dosage

Share to Genetic Variation

Share to Genomic Instability

Share to Germ Cells

Share to Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 29436367
DOI: 10.7554/eLife.32421
PMCID: PMC5811208

Genes

GSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transgenerational dynamics of rDNA copy number in Drosophila male germline stem cells.PMID 29436367Read ↗

Transgenerational dynamics of rDNA copy number in <i>Drosophila</i> male germline stem cellsSemantic proximity Read ↗

Non-random sister chromatid segregation mediates rDNA copy number maintenance in <i>Drosophila</i>Semantic proximity Read ↗

RNA polymerase II-mediated rDNA transcription mediates rDNA copy number expansion in DrosophilaSemantic proximity Read ↗

Multi-generational silencing dynamics control cell agingSemantic proximity Read ↗

Insulin signaling regulates R2 retrotransposon expression to orchestrate transgenerational rDNA copy number maintenanceSemantic proximity Read ↗

The Y chromosome contributes to sex-specific aging in DrosophilaSemantic proximity Read ↗

The retrotransposon <i>R2</i> maintains <i>Drosophila</i> ribosomal DNA repeatsSemantic proximity Read ↗

Insights into ribosomal DNA dominance and magnification through characterization of isogenic deletion alleles.Semantic proximity Read ↗

Ribosomal DNA contributes to global chromatin regulation.Semantic proximity Read ↗

Genomic copy-number loss is rescued by self-limiting production of DNA circlesSemantic proximity Read ↗

Multigenerational silencing dynamics control cell agingSemantic proximity Read ↗

Defects in the NuA4 acetyltransferase complex increase stability of the ribosomal RNA gene and extend replicative lifespan.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.