Article

RNA polymerase II-mediated rDNA transcription mediates rDNA copy number expansion in Drosophila

2024-01-11

Abstract excerpt

Ribosomal DNA (rDNA), which encodes ribosomal RNA, is an essential but unstable genomic element due to its tandemly repeated nature. rDNA’s repetitive nature causes spontaneous intrachromatid recombination, leading to copy number (CN) reduction, which must be counteracted by a mechanism that recovers CN to sustain cells’ viability. Akin to telomere maintenance, rDNA maintenance is particularly important in cell ty...

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Literature Corpus work: c71f39c3-4405-5519-8400-913255c1e12c
DOI: 10.1101/2024.01.11.575146

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